FLInt: single shot safe harbor transgene integration via Fluorescent Landmark Interference.

doi:10.1093/g3journal/jkad041

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Article

FLInt: single shot safe harbor transgene integration via Fluorescent Landmark Interference.

G3 (Bethesda, Md.) - 2 May 2023

Malaiwong Nawaphat, Porta-de-la-Riva Montserrat, Krieg Michael

Abstract excerpt

The stable incorporation of transgenes and recombinant DNA material into the host genome is a bottleneck in many bioengineering applications. Due to the low efficiency, identifying the transgenic animals is often a needle in the haystack. Thus, optimal conditions require efficient screening procedures, but also known and safe landing sites that do not interfere with host expression, low input material and strong...

Topics

Animals
Transgenes
Animals, Genetically Modified
Genome
Chromosomes
Phenotype
CRISPR-Cas Systems

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Identifiers

PMID: 36805659
DOI: 10.1093/g3journal/jkad041
PMCID: PMC10151404

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