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The application of somatic CRISPR-Cas9 to conditional genome editing in Caenorhabditis elegans.

Genesis (New York, N.Y. : 2000) - 1 Apr 2016

Li Wei, Ou Guangshuo

Abstract excerpt

Forward and reverse genetic approaches have been well developed in the nematode Caenorhabditis elegans; however, efficient genetic tools to generate conditional gene mutations are still in high demand. Recently, the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated protein 9 (CRISPR-Cas9) system for genome modification has provided an additional tool for C. elegans researchers to achieve...

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PMID: 26934570
DOI: 10.1002/dvg.22932

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