Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure

2 Feb 2023

Abstract excerpt

Type 2 diabetes (T2D) is associated with β-cell dedifferentiation. Aldehyde dehydrogenase 1 isoform A3 (ALHD1A3) is a marker of β-cell dedifferentiation and correlates with T2D progression. However, it is unknown whether ALDH1A3 activity contributes to β-cell failure, and whether the decrease of ALDH1A3-positive β-cells (A+) following pair-feeding of diabetic animals is due to β-cell restoration. To tackle these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Diabetes Management and Research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36732513
DOI: 10.1038/s41467-023-36315-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failurePMID 36732513Read ↗

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.Semantic proximity Read ↗

Pancreatic β-cell failure, clinical implications, and therapeutic strategies in type 2 diabetesSemantic proximity Read ↗

Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challengesSemantic proximity Read ↗

Alterations in Beta Cell Identity in Type 1 and Type 2 DiabetesSemantic proximity Read ↗

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetesSemantic proximity Read ↗

Transplantation models to characterize the mechanisms of stem cell-induced islet regeneration.Semantic proximity Read ↗

Pancreatic β-cell neogenesis by direct conversion from mature α-cells.Semantic proximity Read ↗

β-Cell Maturation and Identity in Health and Disease.Semantic proximity Read ↗

Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.Semantic proximity Read ↗

Minireview: β-Cell Replacement Therapy for Diabetes in the 21st Century: Manipulation of Cell Fate by Directed DifferentiationSemantic proximity Read ↗

Resolving human α <i>versus</i> β cell fate allocation for the generation of stem cell-derived isletsSemantic proximity Read ↗

Islet cell plasticity and regenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.