Article

Resolving human α <i>versus</i> β cell fate allocation for the generation of stem cell-derived islets

2024-06-21

Abstract excerpt

Generating stem cell-derived glucagon-producing α (SC-α cells) and insulin-producing β cells (SC-β cells) allows to engineer an in vitro biomimetic of the islet of Langerhans, the micro-organ controlling blood glucose, however, there is still a major knowledge gap in the mode and mechanism by which human SC-α and β cells are specified. Mouse studies postulated that Aristaless Related homeobox (Arx) and Paired box...

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Literature Corpus work: 4b09a6ba-ab21-5d60-9974-6f76418e55d8
DOI: 10.1101/2024.06.20.599862

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