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Pancreatic β-cell neogenesis by direct conversion from mature α-cells.

Stem cells (Dayton, Ohio) - 1 Sept 2010

Chung Cheng-Ho, Hao Ergeng, Piran Ron, Keinan Ehud, Levine Fred

Abstract excerpt

Because type 1 and type 2 diabetes are characterized by loss of β-cells, β-cell regeneration has garnered great interest as an approach to diabetes therapy. Here, we developed a new model of β-cell regeneration, combining pancreatic duct ligation (PDL) with elimination of pre-existing β-cells with alloxan. In this model, in which virtually all β-cells observed are neogenic, large numbers of β-cells were generated...

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Identifiers

PMID: 20653050
DOI: 10.1002/stem.482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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