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Article

Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes

10 Aug 2019

Abstract excerpt

PURPOSE OF REVIEW: To discuss the current understanding of "β cell identity" and factors underlying altered identity of pancreatic β cells in diabetes, especially in humans. RECENT FINDINGS: Altered identity of β cells due to dedifferentiation and/or transdifferentiation has been proposed as a mechanism of loss of β cells in diabetes. In dedifferentiation, β cells do not undergo apoptosis; rather, they lose their...

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PMID: 31401713
DOI: 10.1007/s11892-019-1194-6

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