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Article

Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.

Diabetologia - 1 Jan 2016

Anastasiou Vivian, Ninou Elpiniki, Alexopoulou Dimitra, Stertmann Julia, Müller Andreas, Dahl Andreas, Solimena Michele, Speier Stephan, Serafimidis Ioannis, Gavalas Anthony

Abstract excerpt

AIMS/HYPOTHESIS: Pancreatic beta cells maintain glucose homeostasis and beta cell dysfunction is a major risk factor in developing diabetes. Therefore, understanding the developmental regulatory networks that define a fully functional beta cell is important for elucidating the genetic origins of the disease. Aldehyde dehydrogenase activity has been associated with stem/progenitor cells and we have previously...

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Identifiers

PMID: 26518685
DOI: 10.1007/s00125-015-3784-4
PMCID: PMC4670456

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