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Article

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.

Nature communications - 30 Aug 2016

Kim-Muller Ja Young, Fan Jason, Kim Young Jung R, Lee Seung-Ah, Ishida Emi, Blaner William S, Accili Domenico

Abstract excerpt

Insulin-producing β cells become dedifferentiated during diabetes progression. An impaired ability to select substrates for oxidative phosphorylation, or metabolic inflexibility, initiates progression from β-cell dysfunction to β-cell dedifferentiation. The identification of pathways involved in dedifferentiation may provide clues to its reversal. Here we isolate and functionally characterize failing β cells from...

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Identifiers

PMID: 27572106
DOI: 10.1038/ncomms12631
PMCID: PMC5013715

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RICTOR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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