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Article

β-Cell Maturation and Identity in Health and Disease.

International journal of molecular sciences - 30 Oct 2019

Salinno Ciro, Cota Perla, Bastidas-Ponce Aimée, Tarquis-Medina Marta, Lickert Heiko, Bakhti Mostafa

Abstract excerpt

The exponential increase of patients with diabetes mellitus urges for novel therapeutic strategies to reduce the socioeconomic burden of this disease. The loss or dysfunction of insulin-producing β-cells, in patients with type 1 and type 2 diabetes respectively, put these cells at the center of the disease initiation and progression. Therefore, major efforts have been taken to restore the β-cell mass by...

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Identifiers

PMID: 31671683
DOI: 10.3390/ijms20215417
PMCID: PMC6861993

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