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Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challenges

21 Jul 2021

Abstract excerpt

The most distinctive pathological characteristics of diabetes mellitus induced by various stressors or immune-mediated injuries are reductions of pancreatic islet β-cell populations and activity. Existing treatment strategies cannot slow disease progression; consequently, research to genetically engineer β-cell mimetics through bi-directional plasticity is ongoing. The current consensus implicates β-cell...

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PMID: 34289444
DOI: 10.1530/ec-21-0260

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