Article

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetes

2019-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Type 2 Diabetes is associated with defective insulin secretion, reduced β-cell mass, and increased glucagon production. Cell lineage-tracing in rodents and human autopsy surveys support the notion of β-cell dedifferentiation as a unifying mechanism for these abnormalities. Yet, mechanistic determinants of human β-cell failure remain elusive. Using regulatory-network-based single-cell analysis of...

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Literature Corpus work: 91f0f02e-d2fc-5d4a-95c3-76af60ce1dc3
DOI: 10.1101/768135

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