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Biologic features and clinical outcomes in newly diagnosed myelodysplastic syndrome with KMT2A rearrangements

20 Jan 2023

Abstract excerpt

Myeloid neoplasms with KMT2A (previously called MLL) gene rearrangements result from translocations involving KMT2A located on chromosome 11q23 and various partner genes, most often MLLT3, AF4, ENL, and ELL.1 KMT2Ar AML in adults is inherently chemotherapy resistant and patients have a poor prognosis, although recent clinical trials with menin inhibitors (which regulate aberrant gene expression consequent to...

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PMID: 36661399
DOI: 10.1002/ajh.26858

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