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Article

Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications - a HARMONY study.

Leukemia - 1 Sept 2024

Hernández-Sánchez Alberto, González Teresa, Sobas Marta, Sträng Eric, Castellani Gastone, Abáigar María, Valk Peter J M, Villaverde Ramiro Ángela, Benner Axel, Metzeler Klaus H, Azibeiro Raúl, Tettero Jesse M, Martínez-López Joaquín, Pratcorona Marta, Martínez Elicegui Javier, Mills Ken I, Thiede Christian, Sanz Guillermo, Döhner Konstanze, Heuser Michael, Haferlach Torsten, Turki Amin T, Reinhardt Dirk, Schulze-Rath Renate, Barbus Martje, Hernández-Rivas Jesús María, Huntly Brian, Ossenkoppele Gert, Döhner Hartmut, Bullinger Lars

Abstract excerpt

Balanced rearrangements involving the KMT2A gene (KMT2Ar) are recurrent genetic abnormalities in acute myeloid leukemia (AML), but there is lack of consensus regarding the prognostic impact of different fusion partners. Moreover, prognostic implications of gene mutations co-occurring with KMT2Ar are not established. From the HARMONY AML database 205 KMT2Ar adult patients were selected, 185 of whom had mutational...

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Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to High-Throughput Nucleotide Sequencing

Share to Histone-Lysine N-Methyltransferase

Share to Leukemia, Myeloid, Acute

Share to Myeloid-Lymphoid Leukemia Protein

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Share to Translocation, Genetic

Source

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Identifiers

PMID: 38965370
DOI: 10.1038/s41375-024-02333-4
PMCID: PMC11347382

Genes

KMT2A
KRAS
DNMT3A
MLLT3
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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