Article
Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A.
Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2020
Bill Marius, Mrózek Krzysztof, Kohlschmidt Jessica, Eisfeld Ann-Kathrin, Walker Christopher J, Nicolet Deedra, Papaioannou Dimitrios, Blachly James S, Orwick Shelley, Carroll Andrew J, Kolitz Jonathan E, Powell Bayard L, Stone Richard M, de la Chapelle Albert, Byrd John C, Bloomfield Clara D
Abstract excerpt
Balanced rearrangements involving the KMT2A gene, located at 11q23, are among the most frequent chromosome aberrations in acute myeloid leukemia (AML). Because of numerous fusion partners, the mutational landscape and prognostic impact of specific 11q23/KMT2A rearrangements are not fully understood. We analyzed clinical features of 172 adults with AML and recurrent 11q23/KMT2A rearrangements, 141 of whom had...
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