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Article

Characteristics and outcomes of newly diagnosed acute myeloid Leukemia with KMT2A rearrangements.

Leukemia - 1 Jul 2025

Bataller Alex, Goulart Hannah E, Issa Ghayas C, DiNardo Courtney D, Daver Naval, Kadia Tapan, Bazinet Alexandre, Bouligny Ian M, Senapati Jayastu, Haddad Fadi G, Borthakur Gautam, Sasaki Koji, Short Nicholas J, Yilmaz Musa, Montalban-Bravo Guillermo, Tang Guiling, Loghavi Sanam, Garcia-Manero Guillermo, Ravandi Farhad, Kantarjian Hagop, Jabbour Elias

Abstract excerpt

Acute myeloid leukemia (AML) with KMT2A rearrangement (KMT2Ar) has poor outcomes. We analyzed 1,611 patients with AML and 4.3% demonstrated rearrangements in KMT2A. Signaling-related genes (NRAS 30%, KRAS 23% and FLT3-TKD 16%) were the most frequently mutated in patients with KMT2Ar AML. Patients treated with intensive chemotherapy (IT) achieved a complete remission (CR)/CR with incomplete blood count recovery...

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Identifiers

PMID: 40346311
DOI: 10.1038/s41375-025-02634-2

Genes

KMT2A
EFS
KRAS
FLT3
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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