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Article

Acute myeloid leukaemia (AML) harbouring KMT2A-PTD: should it be considered as a myelodysplasia-related abnormality?

Journal of clinical pathology - 17 Apr 2026

Kannan Narasimhapriyan, Achrekar Aarti, Terse Vishram, Gawde Vaibhav, Joshi Swapnali, Bhanshe Prasanna, Chaudhary Shruti, Salunke Pratiksha, Ghogale Sitaram, Deshpande Nilesh, Shetty Dhanlaxmi, Shetty Alok, Mirgh Sumeet, Nayak Lingaraj, Gokarn Anant, Punatar Sachin, Jain Hasmukh, Bagal Bhausaheb, Sengar Manju, Khattry Navin, Rajpal Sweta, Chatterjee Gaurav, Tembhare Prashant, Subramanian Papagudi G, Patkar Nikhil

Abstract excerpt

AIMS: Although acute myeloid leukaemia (AML), myelodysplasia-related (AML-MR), can be defined solely by molecular abnormalities, legacy studies did not analyse the KMT2A gene. The KMT2A-partial tandem duplication (KMT2A-PTD) is described in myelodysplastic neoplasms (MDS) as well as AML. We describe the clinical, morphological, immunophenotypic and molecular features of AML harbouring KMT2A-PTD. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

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Source

Identifiers

PMID: 41819800
DOI: 10.1136/jcp-2025-210460

Genes

KMT2A
CD177
CD7
DNMT3A
FLT3
IDH2
RUNX1
U2AF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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