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Article

Characteristics and Prognostic Implications in Newly Diagnosed KMT2Ar AML: A Multicenter Study of the ECLA Group.

American journal of hematology - 1 Aug 2026

Pan Jiajia, Fu Chunmei, Ling Qing, Lu Ying, Shi Yifen, Zhang Yunxiang, Wang Shaoyuan, Ji Chunyan, Qian Shenxian, Huang Zhenqi, Ge Zheng, Zhang Jingcheng, Ouyang Guifang, Jin Chenghao, Lu Quanyi, Huang Li, Kong Hongwei, Zhu Yu, Yan Zhiling, Liu Debin, Jiang Huawei, Chen Nianci, Lin Xiangjie, Zhou Yile, Zhang Yi, Li Xia, Tong Hongyan, Jin Jie, Chen Suning, Wang Huafeng

Abstract excerpt

Acute myeloid leukemia (AML) harboring KMT2A rearrangement (KMT2Ar) was generally associated with poor prognosis. We enrolled 490 patients with KMT2Ar from the East China Leukemia Alliance between March 2013 and August 2025. KMT2A::MLLT3 was the most frequent KMT2Ar (31.6%), followed by KMT2A::MLLT4 (25.1%), KMT2A::ELL (20%), and KMT2A::MLLT10 (12.7%). KMT2A::MLLT4 showed an inferior prognosis. The most...

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Identifiers

PMID: 42187108
DOI: 10.1002/ajh.70377
PMCID: PMC13331638

Genes

KMT2A
EFS
ELL
FLT3
KRAS
MLLT10
MLLT3
NRAS
PTPN11
TET2
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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