Acute Myeloid Leukemias with Alterations of Lysine Methyltransferase 2A (KMT2A): Recent Therapeutic Developments

Abstract excerpt

Chromosomal rearrangements involving the Lysine Methyl Transferase 2 A (KMT2A) define a genetically distinct subset of acute myeloid leukemia (AML) in about 10% of cases in adult patients; the frequency of KMT2A-r is higher in pediatric AML. Translocations involving the KMT2A-locus at chromosome 11q23 result in the formation of a chimeric oncogene partner, where the N-terminal part of KMT2A is fused to a variety o...

Topics

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• Acute Lymphoblastic Leukemia research
• Acute Myeloid Leukemia Research
• Epigenesis, Genetic
• Histone Deacetylase Inhibitors Research
• Histone-Lysine N-Methyltransferase
• Leukemia, Myeloid, Acute
• Myeloid-Lymphoid Leukemia Protein
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

cb7e6bca-4eab-5d46-b8a2-224472f0173e

DOI

10.20944/preprints202603.1769.v1