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Insights into KMT2A rearrangements in acute myeloid leukemia: from molecular characteristics to targeted therapies

13 May 2025

Abstract excerpt

Acute myeloid leukemia (AML) with KMT2A rearrangements (KMT2A-r) represents a highly aggressive and prognostically unfavorable subtype of leukemia, often resistant to standard treatments and associated with high relapse rates. KMT2A-r, found in 3-10% of adult AML cases, disrupt epigenetic regulation by forming chimeric proteins that activate oncogenic pathways like HOXA and MEIS1. These fusion proteins recruit...

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PMID: 40361241
DOI: 10.1186/s40364-025-00786-y

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