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KMT2A Rearrangements in Leukemias: Molecular Aspects and Therapeutic Perspectives

20 Aug 2024

Abstract excerpt

KMT2A (alias: mixed-lineage leukemia [MLL]) gene mapping on chromosome 11q23 encodes the lysine-specific histone N-methyltransferase 2A and promotes transcription by inducing an open chromatin conformation. Numerous genomic breakpoints within the KMT2A gene have been reported in young children and adults with hematologic disorders and are present in up to 10% of acute leukemias. These rearrangements describe...

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PMID: 39201709
DOI: 10.3390/ijms25169023

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