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Article

Predictors of outcomes in adults with acute myeloid leukemia and KMT2A rearrangements.

Blood cancer journal - 29 Sept 2021

Issa Ghayas C, Zarka Jabra, Sasaki Koji, Qiao Wei, Pak Daewoo, Ning Jing, Short Nicholas J, Haddad Fadi, Tang Zhenya, Patel Keyur P, Cuglievan Branko, Daver Naval, DiNardo Courtney D, Jabbour Elias, Kadia Tapan, Borthakur Gautam, Garcia-Manero Guillermo, Konopleva Marina, Andreeff Michael, Kantarjian Hagop M, Ravandi Farhad

Abstract excerpt

Acute myeloid leukemia (AML) with rearrangement of the lysine methyltransferase 2a gene (KMT2Ar) has adverse outcomes. However, reports on the prognostic impact of various translocations causing KMT2Ar are conflicting. Less is known about associated mutations and their prognostic impact. In a retrospective analysis, we identified 172 adult patients with KMT2Ar AML and compared them to 522 age-matched patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 34588432
DOI: 10.1038/s41408-021-00557-6
PMCID: PMC8481264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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