Article

Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart

2022-07-13

Abstract excerpt

Sex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular programs within individual cell types vary across individuals by age and sex remains poorly characterized. To better understand this variation, we performed single-nucleus combinatorial indexing (sci) ATAC- and RNA-...

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Literature Corpus work: 9c59095d-b384-50ef-b216-c2898422c291
DOI: 10.1101/2022.07.12.496461

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