Article

Context-dependent requirement of H3K9 methyltransferase activity during cellular reprogramming to iPSCs

2019-05-10

Abstract excerpt

<h4>SUMMARY</h4> Methylation of histone 3 at lysine 9 (H3K9) is widely regarded as a major roadblock for cellular reprogramming and interference with associated methyltransferases such as EHMT1 and EHMT2 (also known as GLP and G9A, respectively) increases the efficiencies at which induced pluripotent stem cells (iPSCs) can be derived. Activation of histone and DNA demethylases by ascorbic acid (AA) has become a c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e745f9f0-0b1d-55ec-a7a0-f3973bf62aac
DOI: 10.1101/634949

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Context-dependent requirement of H3K9 methyltransferase activity during cellular reprogramming to iPSCsDOI 10.1101/634949Read

Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/bSemantic proximity Read

The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cellsSemantic proximity Read

Chromatin alterations in the aging lung change progenitor cell activitySemantic proximity Read

H3K36 Methylation - a Guardian of Epigenome IntegritySemantic proximity Read

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem CellsSemantic proximity Read

Antagonistic H3K79me-H3K9ac crosstalk determines elongation at housekeeping genes to promote pluripotencySemantic proximity Read

EHMT2 Inactivation in Pancreatic Epithelial Cells Shapes the Transcriptional Landscape and Inflammation Response of the Whole PancreasSemantic proximity Read

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.Semantic proximity Read

<i>DNMT3A</i> knockouts in human iPSCs prevent <i>de novo</i> DNA methylation and reveal growth advantage during hematopoietic differentiationSemantic proximity Read

PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome.Semantic proximity Read

<i>De novo EHMT2</i> variants cause an autosomal dominant <i>EHMT2</i> -related Kleefstra syndrome via loss of G9a methyltransferase activitySemantic proximity Read

Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.Semantic proximity Read