Article

Distinct roles of glutamine metabolism in benign and malignant cartilage tumors with <i>IDH</i> mutations

2021-09-13

Abstract excerpt

Enchondromas and chondrosarcomas are common cartilage neoplasms that are either benign or malignant respectively. The majority of these tumors harbor mutations in either IDH1 or IDH2. Glutamine metabolism has been implicated as a critical regulator of tumors with IDH mutations. Chondrocytes and chondrosarcomas with mutations in the IDH1 or IDH2 genes showed enhanced glutamine utilization in downstream metabol...

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Literature Corpus work: 7ca152cd-2e2c-520c-a504-bf752b74c383
DOI: 10.1101/2021.09.12.459996

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