Article

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of <i>MYC</i> expression

2025-04-19

Abstract excerpt

<h4>ABSTRACT</h4> High levels of L- and D-2-hydroxyglutarate, the reduced forms of α-ketoglutarate (αKG), are implicated in human neurodevelopmental disorders and cancer. Both enantiomers exert effects on epigenetics by modulating a family of αKG-dependent dioxygenases involved in histone, DNA and RNA demethylation. L-2HG dehydrogenase (L2HGDH) converts L-2HG to αKG. Its deficiency is a rare, autosomal recessive...

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Literature Corpus work: cdef6c91-31f1-5eee-9d6b-725612cbfa6e
DOI: 10.1101/2025.04.16.649033

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