Article
Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2022
Zhang Hongyuan, Puviindran Vijitha, Nadesan Puviindran, Ding Xiruo, Shen Leyao, Tang Yuning J, Tsushima Hidetoshi, Yahara Yasuhito, Ban Ga I, Zhang Guo-Fang, Karner Courtney M, Alman Benjamin A
Abstract excerpt
Enchondromas and chondrosarcomas are common cartilage neoplasms that are either benign or malignant, respectively. The majority of these tumors harbor mutations in either IDH1 or IDH2. Glutamine metabolism has been implicated as a critical regulator of tumors with IDH mutations. Using genetic and pharmacological approaches, we demonstrated that glutaminase-mediated glutamine metabolism played distinct roles in...
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