Article

Targeting glutamine metabolism in hepatic stellate cells alleviates liver fibrosis

2022-08-25

Abstract excerpt

<title>Abstract</title> <p>Glutamine metabolism plays an essential role in cell growth. Glutamate dehydrogenase (GDH) is a key enzyme in glutamine metabolism, promoting the metabolism of glutamate and glutamine and generating ATP, the level of which is profoundly increased in multiple human cancers. Through <italic>in vitro</italic> and<italic> in vivo</italic> experiments, we verified that the small-molecule GDH...

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Literature Corpus work: 0c6606f8-81f9-5c04-bdef-1cb5c09373f8
DOI: 10.21203/rs.3.rs-1953130/v1

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