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Article

Polygenic risk scores for Alzheimer's disease in relation to cognitive change: A representative sample from the general population followed over 16 years.

Neurobiology of disease - 1 Dec 2023

Najar Jenna, Thorvaldsson Valgeir, Kern Silke, Skoog Johan, Waern Margda, Zetterberg Henrik, Blennow Kaj, Skoog Ingmar, Zettergren Anna

Abstract excerpt

BACKGROUND: Polygenic risk scores for Alzheimer's disease (AD-PRSs) have been associated with cognition. However, few studies have examined the effect of AD-PRS beyond the APOE gene, and the influence of genetic variants related to level of cognitive ability (COG-PRS) on cognitive performance over time in the general older population. METHOD: A population-based sample of 965 individuals born in 1930, with genetic...

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PMID: 37977433
DOI: 10.1016/j.nbd.2023.106357

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