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Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives

1 Jan 2021

Abstract excerpt

Abstract Introduction Studies examining the effect of polygenic risk scores (PRS) for Alzheimer's disease (AD) and apolipoprotein E ( APOE ) genotype on incident dementia in very old individuals are lacking. Methods A population‐based sample of 2052 individuals ages 70 to 111, from Sweden, was followed in relation to dementia. AD‐PRSs including 39, 57, 1333, and 13,942 single nucleotide polymorphisms (SNPs) were...

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PMID: 33532541
DOI: 10.1002/dad2.12142

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