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Article

Association of genetic risk of Alzheimer's disease and cognitive function in two European populations.

Scientific reports - 21 Feb 2025

Wang Biqi, Chibnik Lori B, Choi Seung Hoan, Blacker Deborah, DeStefano Anita L, Lin Honghuang

Abstract excerpt

Although there is some evidence of an association between Alzheimer's disease polygenic risk score (AD PRS) and cognitive function, limited validations have been performed in large populations. We investigated the relationship between AD PRS and cognitive function in the UK Biobank in over 276,000 participants and further validated the association in the Alzheimer's Disease Neuroimaging Initiative (ADNI) sample....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39984543
DOI: 10.1038/s41598-025-90277-9
PMCID: PMC11845681

Genes

APOE

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