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Engineered cell entry links receptor biology with single-cell genomics

1 Dec 2022

Abstract excerpt

Cells communicate with each other via receptor-ligand interactions. Here, we describe lentiviral-mediated cell entry by engineered receptor-ligand interaction (ENTER) to display ligand proteins, deliver payloads, and record receptor specificity. We optimize ENTER to decode interactions between T cell receptor (TCR)-MHC peptides, antibody-antigen, and other receptor-ligand pairs. A viral presentation strategy...

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PMID: 36516854
DOI: 10.1016/j.cell.2022.11.016

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