Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo human T cell engineering with enveloped delivery vehicles

11 Jan 2024

Abstract excerpt

Viruses and virally derived particles have the intrinsic capacity to deliver molecules to cells, but the difficulty of readily altering cell-type selectivity has hindered their use for therapeutic delivery. Here, we show that cell surface marker recognition by antibody fragments displayed on membrane-derived particles encapsulating CRISPR-Cas9 protein and guide RNA can deliver genome editing tools to specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to CRISPR and Genetic Engineering
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38212493
DOI: 10.1038/s41587-023-02085-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo human T cell engineering with enveloped delivery vehiclesPMID 38212493Read ↗

Programmable enveloped delivery vehicles for human genome engineering <i>in vivo</i>Semantic proximity Read ↗

Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineeringSemantic proximity Read ↗

NEO-AAV: an engineered extracellular vesicle-enveloped AAV platform for activation-coupled T cell transduction and CAR-T cell generationSemantic proximity Read ↗

A method for polyclonal antigen-specific T cell-targeted genome editing (TarGET) for adoptive cell therapy applicationsSemantic proximity Read ↗

Bioengineering multifunctional extracellular vesicles for targeted delivery of biologics to T cellsSemantic proximity Read ↗

Cell type-specific delivery by modular envelope designSemantic proximity Read ↗

Engineering strategies to safely drive CAR T-cells into the futureSemantic proximity Read ↗

Synthetic Hybrid Receptors for Safer and Programmable T Cell TherapySemantic proximity Read ↗

Emerging Cellular Therapies for CancerSemantic proximity Read ↗

Engineering and Design of Chimeric Antigen ReceptorsSemantic proximity Read ↗

Engineered cell entry links receptor biology with single-cell genomicsSemantic proximity Read ↗

Review: Sustainable Clinical Development of CAR-T Cells – Switching From Viral Transduction Towards CRISPR-Cas Gene EditingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.