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Article

Droplet-based single-cell pairing for high-throughput interaction mapping of antigen-receptor combinations.

Science advances - 12 Dec 2025

Nan Lang, Mao Tianjiao, Chan Charles W F, Wang Bei, Han Ziyu, Choi Gigi C G, Wei Xueyong, Wong Alan S L, Shum Ho Cheung

Abstract excerpt

Mapping the interaction potential of different variant combinations of viral antigens and human cell receptors and understanding how viral antigen mutations interact with human genetic polymorphisms are critical for predicting infection susceptibility and informing precision public health strategies. Here, we develop a droplet-based single-cell pairing and library-on-library interaction screening (SPLIS) system...

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Share to Angiotensin-Converting Enzyme 2
Share to Antigens, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 41385644
DOI: 10.1126/sciadv.aeb1515
PMCID: PMC12700217

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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