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Transitioning from native to synthetic receptors: broadening T-cell engineering and beyond

6 Jun 2025

Abstract excerpt

T-cell immunotherapy has progressed rapidly, evolving from native T-cell receptor biology to the development of innovative synthetic receptors that extend therapeutic applications beyond cancer. This review explores engineering strategies, ranging from natural TCRs to synthetic receptors, that increase T-cell activation and therapeutic potential. We begin by highlighting the foundational role of native receptors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40481182
DOI: 10.1038/s41423-025-01304-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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