Article

Library-based single-cell analysis of CAR signaling reveals drivers of <i>in vivo</i> persistence

2024-05-02

Abstract excerpt

<h4>Summary</h4> The anti-tumor function of engineered T cells expressing chimeric antigen receptors (CARs) is dependent on signals transduced through intracellular signaling domains (ICDs). Different ICDs are known to drive distinct phenotypes, but systematic investigations into how ICD architectures direct T cell function—particularly at the molecular level—are lacking. Here, we use single-cell sequencing to ma...

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Literature Corpus work: 5c40a4ef-ff86-51ca-9523-ea248826831a
DOI: 10.1101/2024.04.29.591541

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