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CAR T cell engineering impacts antigen-independent activation and co-inhibition

2025-01-22

Abstract excerpt

Viral vectors have successfully modified T cells to express chimeric antigen receptors (CAR), leading to clinical approvals. However, their high cost and regulatory challenges hinder rapid and broad clinical translation. Here, we demonstrate that our lentivirally (LV) manufactured R110-CAR T cells, targeting a leukemia neoepitope, can also be engineered using non-viral Sleeping Beauty (SB) transposition with minim...

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Literature Corpus work
b5489af0-e190-5b8b-a946-3ffd3bdf298d
DOI
10.1101/2025.01.20.631849
Open publication

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CAR T cell engineering impacts antigen-independent activation and co-inhibitionDOI 10.1101/2025.01.20.631849
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