Article
Identification of multiplicatively acting modulatory mutational signatures in cancer.
BMC bioinformatics - 6 Dec 2022
Kičiatovas Dovydas, Guo Qingli, Kailas Miika, Pesonen Henri, Corander Jukka, Kaski Samuel, Pitkänen Esa, Mustonen Ville
Abstract excerpt
BACKGROUND: A deep understanding of carcinogenesis at the DNA level underpins many advances in cancer prevention and treatment. Mutational signatures provide a breakthrough conceptualisation, as well as an analysis framework, that can be used to build such understanding. They capture somatic mutation patterns and at best identify their causes. Most studies in this context have focused on an inherently additive...
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