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Article

Robust discovery of mutational signatures using power posteriors.

PLoS computational biology - 1 Jun 2026

Xue Catherine, Miller Jeffrey W, Carter Scott L, Huggins Jonathan H

Abstract excerpt

Mutational processes, such as the molecular effects of carcinogenic agents or defective DNA repair mechanisms, produce different mutation types with characteristic frequency profiles, known as mutational signatures. Non-negative matrix factorization (NMF) has been successfully used to discover many mutational signatures, yielding novel insights into cancer etiology and informing targeted therapies. However, the...

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Identifiers

PMID: 42275462
DOI: 10.1371/journal.pcbi.1014372
PMCID: PMC13274926

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