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Evaluating intrinsic and non-intrinsic cancer risk factors

22 Aug 2018

Abstract excerpt

Discriminating the contribution of unmodifiable random intrinsic DNA replication errors ('bad luck') to cancer development from those of other factors is critical for understanding cancer in humans and for directing public resources aimed at reducing the burden of cancer. Here, we review and highlight the evidence that demonstrates cancer causation is multifactorial, and provide several important examples where...

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PMID: 30154431
DOI: 10.1038/s41467-018-05467-z

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