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Detecting presence of mutational signatures in cancer with confidence

21 Sept 2017

Abstract excerpt

MOTIVATION: Cancers arise as the result of somatically acquired changes in the DNA of cancer cells. However, in addition to the mutations that confer a growth advantage, cancer genomes accumulate a large number of somatic mutations resulting from normal DNA damage and repair processes as well as carcinogenic exposures or cancer related aberrations of DNA maintenance machinery. These mutagenic processes often...

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PMID: 29028923
DOI: 10.1093/bioinformatics/btx604

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