Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two main mutational processes operate in the absence of DNA mismatch repair.

DNA repair - 1 May 2020

Németh Eszter, Lovrics Anna, Gervai Judit Z, Seki Masayuki, Rospo Giuseppe, Bardelli Alberto, Szüts Dávid

Abstract excerpt

The analysis of tumour genome sequences has demonstrated high rates of base substitution mutagenesis upon the inactivation of DNA mismatch repair (MMR), and the resulting somatic mutations in MMR deficient tumours appear to significantly enhance the response to immune therapy. A handful of different algorithmically derived base substitution mutation signatures have been attributed to MMR deficiency in tumour...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cell Line, Tumor
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Gene Knockout Techniques

Share to Mutagenesis

Share to MutS Homolog 2 Protein

Share to Neoplasms

Source

Identifiers

PMID: 32126497
DOI: 10.1016/j.dnarep.2020.102827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two main mutational processes operate in the absence of DNA mismatch repair.PMID 32126497Read ↗

The Repertoire of Mutational Signatures in Human CancerSemantic proximity Read ↗

Five dominant amino acid substitution signatures shape tumour immunity.Semantic proximity Read ↗

Dissecting DNA-mismatch-repair-driven mutational processes in human cellsSemantic proximity Read ↗

Patterns and processes of somatic mutations in nine major cancers.Semantic proximity Read ↗

Damage and Misrepair Signatures: Compact Representations of Pan-cancer Mutational ProcessesSemantic proximity Read ↗

MutationalPatterns: comprehensive genome-wide analysis of mutational processes.Semantic proximity Read ↗

Predicting response to immune checkpoint blockade therapy among mismatch repair-deficient patients using mutational signaturesSemantic proximity Read ↗

Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy.Semantic proximity Read ↗

The therapeutic significance of mutational signatures from DNA repair deficiency in cancer.Semantic proximity Read ↗

Mutational Signatures: From Methods to Mechanisms.Semantic proximity Read ↗

SNMF: Integrated Learning of Mutational Signatures and Prediction of DNA Repair DeficienciesSemantic proximity Read ↗

Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.