Article
Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer.
Genome medicine - 29 May 2020
Kim Yoo-Ah, Wojtowicz Damian, Sarto Basso Rebecca, Sason Itay, Robinson Welles, Hochbaum Dorit S, Leiserson Mark D M, Sharan Roded, Vadin Fabio, Przytycka Teresa M
Abstract excerpt
BACKGROUND: Studies of cancer mutations have typically focused on identifying cancer driving mutations that confer growth advantage to cancer cells. However, cancer genomes accumulate a large number of passenger somatic mutations resulting from various endogenous and exogenous causes, including normal DNA damage and repair processes or cancer-related aberrations of DNA maintenance machinery as well as mutations...
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