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Damage and Misrepair Signatures: Compact Representations of Pan-cancer Mutational Processes

2025-06-01

Abstract excerpt

Mutational signatures of single-base substitutions (SBSs) characterize somatic mutation processes which contribute to cancer development and progression. However, current mutational signatures do not distinguish the two independent steps that generate SBSs: the initial DNA damage followed by erroneous repair. To address this modelling gap we developed DAMUTA, a hierarchical Bayesian probabilistic model that infers...

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Identifiers and source

Literature Corpus work
e53569ce-17cf-5c9c-a7c6-b2ce18b3b724
DOI
10.1101/2025.05.29.656360
Open publication

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Damage and Misrepair Signatures: Compact Representations of Pan-cancer Mutational ProcessesDOI 10.1101/2025.05.29.656360
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