Article

Detecting presence of mutational signatures in cancer with confidence

2017-05-01

Abstract excerpt

Cancers arise as the result of somatically acquired changes in the DNA of cancer cells. However, in addition to the mutations that confer a growth advantage, cancer genomes accumulate a large number of somatic mutations resulting from normal DNA damage and repair processes as well as mutations triggered by carcinogenic exposures or cancer related aberrations of DNA mainte-nance machinery. These mutagenic processes...

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Literature Corpus work: c78de47c-4198-5f4e-a75e-b1b3428cb9dd
DOI: 10.1101/132597

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