Article

A framework for mutational signature analysis based on DNA shape parameters

2020-09-29

Abstract excerpt

The mutation risk of a DNA locus depends on its oligonucleotide context. In turn, mutability of oligonucleotides varies across individuals, due to exposure to mutagenic agents or due to variable efficiency and/or accuracy of DNA repair. Such variability is captured by mutational signatures, a mathematical construct obtained by a deconvolution of mutation frequency spectra across individuals. There is a need to enh...

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Literature Corpus work: 982ae4c2-4951-5e30-be29-30e69cda2b9e
DOI: 10.1101/2020.09.28.316794

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