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Article

The therapeutic significance of mutational signatures from DNA repair deficiency in cancer.

Nature communications - 17 Aug 2018

Ma Jennifer, Setton Jeremy, Lee Nancy Y, Riaz Nadeem, Powell Simon N

Abstract excerpt

Cancer is fundamentally a disease of the genome and inherited deficiencies in DNA repair pathways are well established to increase lifetime cancer risk. Computational analysis of pan-cancer data has identified signatures of mutational processes thought to be responsible for the pattern of mutations in any given cancer. These analyses identified altered DNA repair pathways in a much broader spectrum of cancers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30120226
DOI: 10.1038/s41467-018-05228-y
PMCID: PMC6098043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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