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Article

Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo

23 Nov 2022

Abstract excerpt

DddA-derived cytosine base editors (DdCBEs) use programmable DNA-binding TALE repeat arrays, rather than CRISPR proteins, a split double-stranded DNA cytidine deaminase (DddA), and a uracil glycosylase inhibitor to mediate C•G-to-T•A editing in nuclear and organelle DNA. Here we report the development of zinc finger DdCBEs (ZF-DdCBEs) and the improvement of their editing performance through engineering their...

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PMID: 36418298
DOI: 10.1038/s41467-022-34784-7

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