Article
TadA reprogramming to generate potent miniature base editors with high precision.
Nature communications - 26 Jan 2023
Zhang Shuqian, Song Liting, Yuan Bo, Zhang Cheng, Cao Jixin, Chen Jinlong, Qiu Jiayi, Tai Yilin, Chen Jingqi, Qiu Zilong, Zhao Xing-Ming, Cheng Tian-Lin
Abstract excerpt
Although miniature CRISPR-Cas12f systems were recently developed, the editing efficacy and targeting range of derived miniature cytosine and adenine base editors (miniCBEs and miniABEs) have not been comprehensively addressed. Moreover, functional miniCBEs have not yet be established. Here we generate various Cas12f-derived miniCBEs and miniABEs with improved editing activities and diversified targeting scopes....
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