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Article

Enhanced C-To-T and A-To-G Base Editing in Mitochondrial DNA with Engineered DdCBE and TALED.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jan 2024

Wei Yinghui, Jin Ming, Huang Shuhong, Yao Fangyao, Ren Ningxin, Xu Kun, Li Shangpu, Gao Pengfei, Zhou Yingsi, Chen Yulin, Yang Hui, Li Wen, Xu Chunlong, Zhang Meiling, Wang Xiaolong

Abstract excerpt

Mitochondrial base editing with DddA-derived cytosine base editor (DdCBE) is limited in the accessible target sequences and modest activity. Here, the optimized DdCBE tools is presented with improved editing activity and expanded C-to-T targeting scope by fusing DddA11 variant with different cytosine deaminases with single-strand DNA activity. Compared to previous DdCBE based on DddA11 variant alone, fusion of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37984866
DOI: 10.1002/advs.202304113
PMCID: PMC10797475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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