Article

Engineering TALE-linked deaminases to facilitate precision adenine base editing in mitochondrial DNA

2023-09-05

Abstract excerpt

<h4>ABSTRACT</h4> DddA -derived cytosine base editors (DdCBEs) and transcription activator-like effector (TALE)-linked deaminases (TALEDs) catalyze targeted base editing of mitochondrial DNA (mtDNA) in eukaryotic cells, a method useful for modeling of mitochondrial genetic disorders and developing novel therapeutic modalities. Here, we report that A-to-G editing TALEDs but not C-to-T editing DdCBEs induce tens of...

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Literature Corpus work: 5bddb548-6b97-5258-b222-b0a5434a28d4
DOI: 10.1101/2023.09.03.556141

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